• Selected Publications

Ray A, Callaway MK, Rodríguez-Merced NJ, Crampton AL, Carlson M, Emme KB, Ensminger EA, Kinne AA, Schrope JH, Rasmussen HR, Jiang H, DeNardo DG, Wood DK, Provenzano PP. Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma. JCI Insight. 2021  PMID: 34914633 

Shih ED, Provenzano PP, Witzenburg CM, Barocas VH, Grande AW, Alford PW. Characterizing Tissue Remodeling and Mechanical Heterogeneity in Cerebral Aneurysms.  J Vasc Res. 2021 Nov 10:1-9  PMID: 34758464

Ray A, Provenzano PP. Aligned forces: Origins and mechanisms of cancer dissemination guided by extracellular matrix architecture.   Curr Opin Cell Biol. 2021 Oct;72:63-71. PMID: 34186415

Tabdanov ED,  Rodriguez N*., Puram V, Zhovmer A, Callaway, M, Moriarty B, Provenzano PP Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironmentsNature Communications, 12(1):2815, 2021

Ray A, Provenzano PP Aligned forces: Origins and mechanisms of cancer dissemination guided by extracellular matrix architectureCurr Opin Cell Biol. 72:63-71, 2021

Tawari A, Tashiro K, Dixit A, Campos A, Vogel K, Hall B, Shafqat I, Slaughter J, Param N, Le A, Saunders E, Paithane U, Clarson M, Starr T, Marahrens, Y, Deshpande A, Provenzano PP, Bagchi A. Loss of HIF1α Implicates PPP1R1B as a Novel Metastasis Driver in Pancreatic Cancer. Gastroenterology. 2020

Tabdanov ED, Puram V, Zhovmer A, Provenzano PP, Engineering Elastic Nano- and Micro-Patterns and Textures for Directed Cell MotilityCell Press, STAR Protocols, Feb 28, 2020

Liu Y, Keikhosravi A, Pehlke C, Bredfedlt JS, Duston M, Lui H, Mehta, GS, Claus R, Patel AJ, Conklin MW, Provenzano PP, Sifakis E, Patel JM, Eliceiri KW, Fibrillar Collagen Quantification with Curvelet Transform Based Computational MethodsFrontiers in Bioengineering and Biotechnology, Feb 28, 2020

Provenzano PP, Bringing order to the matrixNature Materials 19(2):130-131, 2020. Link

Elahi-Gedwillo K, Carlson M, Zettervall J, Provenzano PP, Antifibrotic therapy disrupts stromal barriers and modulates the immune landscape in pancreatic ductal adenocarcinomaCancer Research 79(2):372-386, 2019. Link

Hou JC, Shamsan GA, Anderson SM, McMahon MM, Tyler LP, Castle BT, Heussner RK, Provenzano PP, Keefe DF, Barocas VH, Odde DJ, Modeling distributed forces within cell adhesions of varying size on continuous substrates.Cytoskeleton 76(11-12):571-585, 2019. Link

Zhovmer AS, Tabdanov ED, Miao H, Wen H, Chen J, Luo X, Ma X, Provenzano PP, Adelstein RS, The role of nonmuscle myosin 2A and 2B in the regulation of mesenchymal cell contact guidance.Molecular Biology of the Cell 30(16):1961-1973, 2019. Link

Maloney E, DuFort CC, Provenzano PP, Farr N, Carlson MA, Vohra R, Park J, Hingorani SR, Lee D, Non-Invasive Monitoring of Stromal Biophysics with Targeted Depletion of Hyaluronan in Pancreatic Ductal Adenocarcinoma.Cancers 11(6), 2019. Link

Tabdanov E, Win Z, Ashab A, Alford PW, Provenzano PP, Bimodal sensing of guidance cues in mechanically complex microenvironmentsNature Communications , 20;9(1):4891, 2018. Link

Tabdanov ED, Puram V, Zhovmer A, Provenzano PP, Microtubule-Actomyosin Mechanical Cooperation During Contact Guidance SensingCell Reports 25, 328–33, 2018. Link

Ray A, Morford RK, Ghaderi N, Odde DJ, Provenzano PP, Dynamics of 3D carcinoma cell invasion into aligned collagenIntegrative Biology 19;10(2):100-112, 2018. Link

Shao Q, Liu F, Chung C, Elahi-Gedwillo K, Provenzano PP, Forsyth B, Bischof J, Physical and chemical enhancement of and adaptive resistance to irreversible electroporation of pancreatic cancernAnnals of Biomedical Engineering 46(1):25-36, 2018. Link

Carlson M*, Watson A*, Anderson L, Largaespada D, Provenzano PP, Multiphoton fluorescence lifetime imaging of chemotherapy distribution in solid tumorsJournal of Biomedical Optics 22(11):1-9, 2017. Link

Ray A, Lee O, Win Z, Edward RM, Alford PW, Kim DH, Provenzano PP, Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migrationNature Communications 8:14923, 2017. Link

Provenzano PP, Tug of war at the cell-matrix interfaceBiophysical Journal 9;112(9):1739-1741, 2017. Link

Ray A, Slama ZM, Morford RK, Madden SA, Provenzano PP, Enhanced directional migration of cancer stem cells in 3D aligned collagen matricesBiophysical Journal 14;112(5):1023-1036, 2017. Supp Movie 1

Nam KH, Kim P, Kwon S, Wood DK, Provenzano PP*, Kim DH* Multiscale cues drive collective cell migrationScientific Reports 6, 29749, 2016 (*Co-corresponding / senior authors) PMC27460294

DuFort CC, DelGiorno KE, Carlson MA, Osgood RJ, Zhao C, Huang Z, Thompson CB, Connor RJ, Thanos CD, Scott Brockenbrough J, Provenzano PP, Frost GI, Michael Shepard H, Hingorani SR Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase. Biophys J 10(9), 2106-19, 2016

Jung JP, Bache-Wiig MK, Provenzano PP, Ogle BM Heterogeneous Differentiation of Human Mesenchymal Stem Cells in 3D Extracellular Matrix Composites. Bioresearch OA 5(1), 37-48, 2016 PMC4744874

DelGiorno KE, Carlson MA, Osgood R, Provenzano PP, Brockenbough JS, Thompson CB, Shepard HM, Frost GI, Potter JD, Hingorani SR Interstitial pressure and vascular collapse in pancreas cancer-fluids and solids, measurement and meaning (Response to Chauhan et al.). Cancer Cell 26(1), 16-7, 2014 PMC4465109

Provenzano PP, Hingorani SR Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer. British Journal of Cancer 108(1), 1-8, 2013 PMC3553539

Provenzano PP, Cuevas C, Chang AE, Von Hoff DD, Hingorani SR Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma Cancer Cell 21(3), 418-429, 2012 PMC3371414

Kim DH, Provenzano PP, Smith CL, Levchenko A Matrix nanotopography as a regulator of cell function Journal of Cell Biology (review) 197(3), 351-60, 2012 PMC3341161

Provenzano PP, Keely PJ Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase singaling Journal of Cell Science (review) 124(8), 1195-1205, 2011 PMC3065381

Conklin MW, Eickhoff JC, Riching KM, Pehlke CA, Eliceiri KW, Provenzano PP, Friedl A, Keely PJ Aligned collagen is a prognostic signature for survival in human breast carcinoma American Journal of Pathology178(3): 1221-1232, 2011 PMC3070581

Provenzano PP, Eliceiri KW, Keely PJ, Shining new light on 3D motility and the metastatic process Shining new light on 3D motility and the metastatic process Trends in Cell Biology (review) 19(11): 638-648, 2009 PMC2783928

Rueden CT, Conklin MW, Provenzano PP, Keely PJ, Eliceiri KW Nonlinear optical microscopy and computational analysis of intrinsic signatures in breast cancer Proc IEEE Eng. Med. Biol. Soc. 4077-4090, 2009

Provenzano PP, Inman DR, Eliceiri KW, Keely PJ Matrix density-induced stiffness regulates breast cell phenotype, signaling, and gene expression through a FAK-ERK linkage Oncogene 28(49): 4326-4343, 2009 10008-13. PMC2795025

Provenzano PP, Inman DR, Eliceiri KW, Keely PJ Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment Clinical & Experimental Metastasis – Special Issue: Imaging the Dynamics of Cancer (invited review) 26(4): 357-70, 2009

Conklin MW, Provenzano PP, Eliceiri KW, Sullivan R, Keely PJ Fluorescence lifetime imaging of endogenous fluorophores in histopathology sections reveals differences between normal and tumor epithelium in carcinoma in situ of the breast Cell Biochemistry and Biophysics 53(3): 145-157, 2009

Provenzano PP, Inman DR, Trier SM, Eliceiri KW, Keely PJ Contact guidance mediated 3D cell migration is regulated by Rho/ROCK-dependent matrix reorganization Biophysical Journal 95: 5374-5384, 2008 PMC2586586

Provenzano PP, Inman DR, Eliceiri KW, Beggs HE, Keely PJ Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer American Journal of Pathology 173(5): 1551-1565, 2008 PMC2570144

Provenzano PP, Rueden CT, Trier SM, Yan L, Ponik SM, Inman DR, Keely PJ, and Eliceiri KW Nonlinear optical imaging and spectral-lifetime computational analysis of endogenous and exogenous fluorophores in breast cancer Journal of Biomedical Optics 13(3): 031220, 2008

Provenzano PP, Inman DR, Eliceiri KW, Knittel JG, White JG, Keely PJ Collagen density promotes mammary tumor initiation and progression BMC Medicine 6(11): 2008 PMC2386807

Provenzano PP, Eliceiri KW, Campbell JW, Inman DR, White JG, Keely PJ Collagen reorganization at the tumor-stromal interface facilitates local invasion BMC Medicine 34(1): 2006 PMC2386807

Provenzano PP, Vanderby Jr. R Collagen fibril morphology and organization: Implications for force transmission in ligament and tendon Matrix Biology 25: 71-84, 2006

Provenzano PP, Alejandro-Osorio AL, Valhmu WB, Jensen KT, Vanderby Jr. R Intrinsic fibroblast mediated remodeling of damaged collagenous matrices in vivo Matrix Biology 23: 543-555, 2005

Hingorani R, Provenzano PP, Lakes RS, Vanderby Jr. R Nonlinear viscoelasticity in rabbit medial collateral ligament Annals of Biomedical Engineering 32(2): 306-312, 2004

Provenzano PP, Martinez DA, Grindeland RE, Turner J, Dwyer KW, Vailas AC, Vanderby Jr. R Hindlimb unloading alters ligament healing Journal of Applied Physiology 94 (1): 314-324, 2003

Hurschler C, Provenzano PP, Vanderby Jr. R Application of a probabilistic microstructural model to determine reference length and toe-to-linear region transition in fibrous connective tissue Journal of Biomechanical Engineering 125(3): 415-422, 2003

Provenzano PP, Rutland CJ A boundary layer model for wall shear stress in arterial stenosis Biorheology 39(6): 743-754, 2002

Provenzano PP, Heisey D, Hayashi K, Lakes RS, Vanderby Jr. R Sub-failure damage in ligament: A structural and cellular evaluation Journal of Applied Physiology 92(1): 362-371, 2002

Provenzano PP, Lakes RS, Corr DT, Vanderby Jr. R Application of nonlinear viscoelastic models to describe ligament behavior Biomechanics and Modeling in Mechanobiology 1(1): 45-57, 2002

Provenzano PP, Lakes RS, Keenan TM, Vanderby Jr. R Non-linear ligament viscoelasticity Annals of Biomedical Engineering 29(10): 908-914, 2001

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